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KRAS-mutant CRC cells specifically upregulate LAT1, and deletion of LAT1 impedes the growth and metastasis of CRC tumors [38]

Furthermore, a meta-analysis encompassing 13 studies comprising 1,606 females diagnosed with PCOS revealed that sustained administration of metformin leads to a notable decrease in miscarriage and preterm birth rates, alongside an increase in full-term pregnancies

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Although neutrophils rely on glycolysis to provide most of the energy required for their basic functions ( 2.1 Glucose metabolism Glucose is the major substance used to supply energy in neutrophils ( As progenitor myeloid cells differentiate into neutrophils, their main energy source shifts from oxidative phosphorylation (OXPHOS), which connects the tricarboxylic acid (TCA) cycle with the electron transport train in aerobic respiration, to glycolysis ( Figure 1 )

Metabolism of all ECs is characterized by a reliance on glycolysis for ATP generation in both proliferating and quiescent states, with a notable decrease in glycolytic flux during quiescence (De Bock et al, 2013b